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1 Binjiangyi Road, Chunjiang Town,
Binjiang Fine-chemical Park,
Xinbei District, Changzhou 213127
Jiangsu, China
Contact Person
Linda He
  Tel: 0519-88122965 13775180513
  Email: linda@huarenchem.com
Cao Jing
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  Email: info@huarenchem.com
Amy Zhou
  Tel: 0519-88103998 13646148298
  Email: amy.zhou@huarenchem.com
Miss Yu
  Tel: 0519-88100916 13775081323
  Email: ylp@huarenpharm.com
Fax: ++86 519 8810 4456
Email: sales @ huarenpharm.com

Products | APIs

  Product Name    Sirolimus
  CAS#    53123-88-9
  Synonyms    Rapamycin
  中文名    雷帕霉素; 西罗莫司
  Molecular Formula    C51H79NO13


Description

Biochem/physiol Actions Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Protocols & Applications Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Properties

biological source from Streptomyces hygroscopicus
sterility 0.2 μm filtered
assay ≥95% (HPLC)
concentration 2.5 mg/mL in DMSO (2.74 mM)
EQP level Premium
storage temp. −20°C

Safety

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
WGK Germany 1
UEL 42.00%
LEL 3.50%
Flash Point(F) 189 °F
Flash Point(C) 87 °C

 

  Notice Products protected by valid patents in this list are for laboratory analytical / research purposes only and are not offered for sale in countries where the sale of such products constitutes a patent infringement, its liability is at buyer's risk!